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Secondary brain injury after aneurysmal subarachnoid haemorrhage: more than vasospasm

Calculating concentration and dose Standard PT-141 concentration: 10mg PT-141 + 2ml water = 5mg/ml This is ideal concentration for dosing Alternative: 10mg + 1ml = 10mg/ml (more concentrated, smaller injection volume) Most use 5mg/ml for easier dosing calculations Dose calculation formula: Desired dose (mg) Concentration (mg/ml) = Volume to inject (ml) Example: Want 1.5mg dose, have 5mg/ml concentration 1.5mg 5mg/ml = 0.3ml 0.3ml = 30 units on insulin syringe (1ml = 100 units) Common PT-141 doses: Concentration alternatives: More concentrated (10mg + 1ml = 10mg/ml): Pros: Smaller injection volume, vial lasts longer Cons: Harder to measure small doses accurately Example: 1.5mg dose = 0.15ml (15 units) More dilute (10mg + 4ml = 2.5mg/ml): Pros: Easier precise dosing, gentler injection Cons: Larger injection volume, more water needed Example: 1.5mg dose = 0.6ml (60 units) Recommendation: 5mg/ml standard (10mg + 2ml) works best Easy calculations Reasonable injection volumes Accurate dosing possible Most peptide protocols use this Use our peptide calculator for instant dose calculations

A modified IGF-1 peptide with a 13-residue extension and an Arg substitution at position 3, used to study growth-factor signalling in vitro

Beginner protocol: 1 mg weekly, administered as a single injection or split into two 500mcg doses