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Phentermines stimulant effects persist throughout treatment and can cause other problems
The STEP UP trial, a Phase 3b study published in The Lancet Diabetes & Endocrinology in 2025, evaluated a 7.2 mg weekly injection dose in over 1,400 adults with obesity (BMI of 30 or higher) and without diabetes
This imbalance can disrupt the HPG axis short for the hypothalamic-pituitary-gonadal axis which links the brain and testes to regulate testosterone levels and sperm production
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