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Moreover, existing studies mostly focus on the regulation of RA synovial cells (such as FLS) or macrophages by the cGAS-STING pathway, whereas this study, for the first time, clearly demonstrates the central role of the cGAS-STING-ferroptosis axis in RA chondrocytes, and reveals that GLP-1RAs exerted therapeutic effects on RA through a dual mechanism of directly inhibiting this axis and simultaneously promoting the M2 polarization of macrophages

Many patients report changes within 4-8 weeks, with continued improvement over several months

Identification of melatonin in plants and its effects on plasma melatonin levels and binding to melatonin receptors in vertebrates