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Significant prior efforts across the pharmaceutical industry have failed to identify potent and efficacious small-molecule agonists of the GLP-1R ( 15, 16 )
In Phase 2 trials, retatrutide was administered as a once-weekly subcutaneous injection using a gradual dose escalation schedule to minimise gastrointestinal side effects
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Tirzepatide, sold under brand names like Mounjaro and Zepbound , is becoming more widely used to treat type 2 diabetes and to help with weight loss
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