Acquired GHD occurs due to injuries or damage to the hypothalamus or pituitary gland (e.g., via head trauma, infections, tumors, or treatments such as radiation therapy)
It was initially researched for its properties in wound healing and tissue renewal
Even with this unprecedented incretin power, the extratumoral microenvironment, hyperinsulinemia-driven FAK/PYK2 activation and collagen remodeling in adipose, kidney, liver, and heart, remains untouched and continues to fuel residual progression in 5070 % of obesity, T2D, CKD & HFpEF patients
The REDEFINE 4 trial: the definitive showdown Everything discussed above relies on cross-trial comparisons, which carry inherent limitations