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doi:10.1016/j.obpill.2025.100181 Fitch A, Gigliotti L, Bays HE

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The LR3 extension does not make it "safer" -- it makes it longer-acting and less regulated by binding proteins, which from a risk standpoint means sustained free IGF-1R activation without the IGFBP buffering system that modulates native IGF-1 activity in healthy physiology

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The goal in treating systemic primary carnitine deficiency is to maintain safe carnitine levels in the blood and tissues

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