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Setiawan VW, Pandol SJ, Porcel J, Wei PC, Wilkens LR, Le Marchand L,
Metabolites with a Variables Important in the Projection (VIP) value greater than 1 were considered for evaluation of their role in class separation
It has been demonstrated that in some cases of oral mucosal melanoma, there is loss of the integrity of the melanosomal membrane with leakage into the cytoplasm and nucleoplasm of the melanocytes, of toxic melanin particles, intermediates of melanogenesis and reactive oxygen species, with consequent DNA damage and increase in the risk of genetic mutations [59]
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