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Patients were randomized in a 1:1:1 ratio to once weekly fixed dosage of ZEPBOUND 10 mg, ZEPBOUND 15 mg, or placebo with an escalation period of up to 20 weeks followed by the maintenance period

Subsequently, the drug has been approved across the European Union (September 2022), Canada (November 2022), and Australia (December 2022)

To add to this, VRK2 overexpression significantly attenuated TBHP-mediated cell death, which could be efficiently reversed by BFA treatment (Fig

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