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Weight: People who are overweight tend to have lower glutathione levels than those who are within normal weight range because excess fat is correlated with oxidative (free radical-induced) stress

[15] Ergen and colleagues analyzed gene expression of oxidative stress genes, specifically GPX1, in colorectal tumors in comparison to healthy colorectal tissues

Triggers of elevated ceramide levels comprise hyperosmotic shock [122], secreted sphingomyelinases (SMases) during inflammation [125], sepsis [126] or severe coronavirus disease 2019 (COVID-19) [127], Clostridium perfringens epsilon toxin [128], and platelet-activating factor [129]

This shift can contribute to gradual skin lightening