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The enzyme Tyrosinase plays a pivotal role in the synthesis of this pigment

2019;12:eaav3048 OLeary EM, Tian Y, Nigdelioglu R, Witt LJ, Cetin-Atalay R, Meliton AY, et al

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Interestingly, in a process similar to step 1 of the CSD evolution in D2, modification of the canonical Ig disulfide between strands B and F has also occurred in D1 of some fish CD4 proteins (trout and fugu), which contain a distinct unpaired Cys in strand F, but lack the second Cys in strand B that forms a disulfide in mammalian and bird CD4 molecules