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Injections are once a week at a fee of $90 per injection for Semaglutide and $100 per injection for Tirzepatide for Cycle 1

The perceived cardiovascular risk with certain glucose-lowering agents and evidence that hemoglobin a1c (HbA1c) lowering per se did not significantly reduce cardiovascular risk or mortality led to the regulatory requirement for cardiovascular safety trials for new agents beginning in 2009