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First, it acts as a glutathione-sparing agent by immediately attacking free radicals
In order to increase specificity, this peptide contains a region of the p53 binding site on FOXO4 which differs in primary aminoacids sequence of FOXO1 and 3
Injection of preclinical meningiomas with 8803 induces survival benefits, including in an immunocompetent orthotopic setting, through remodeling of the tumor microenvironment, immune infiltration, and downregulation of tumor-mediated immune suppression, thereby nominating 8803 for treatment consideration in meningiomas
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