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Ashley Koff, RD, a registered dietitian based in Oregon, and the founder of the Better Nutrition program, adds that amylin addresses the reward area of the brain, lessening the dopamine hit you get from eating sugar and fat

If gastrointestinal symptoms persist or significantly impact your quality of life, discuss with your prescriber about adjusting the titration pace or temporarily modifying your dose

GLP-1RAs: Slow down emptying of the stomach after a meal, helping you to feel full for longer

Researchers have proposed that the biased pharmacology contributes to the distinctive effect-size profile observed in SURPASS clinical research, including effects on insulin sensitivity that exceed GLP-1-only agonism