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MC1R / Pigmentation and Photoprotective Signaling PT-141 retains MC1R binding activity, and studies have characterized its capacity to activate the cAMPPKAMITF axis in melanocytes, driving tyrosinase upregulation and eumelanin synthesis, consistent with the signaling profile shared across the MT-2-derived melanocortin agonist class (Hadley & Dorr, Peptides, 2006)

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Phase Early escalation Weeks 5-8 Weekly Dose 4 mg Notes Step up every 4 weeks

It may affect your movement and sensation, especially in your legs, cause numbness or pins and needles and decrease your sensitivity to touch, vibration or pain