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Research has investigated its role in sleep-wake cycle regulation, pituitary hormone secretion, stress adaptation, and nociceptive pathways
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Goal: Selectively clear senescent cells by disrupting the nuclear FOXO4p53 interaction so freed p53 triggers apoptosis demonstrated in preclinical (mouse) work only, not established in humans [1] [2] Schedule: Daily subcutaneous injections across a 16-week course with gradual dose escalation
The researchers are encouraging future investigations with COVID-19 patients
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