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Notwithstanding, previous studies have documented beneficial effects of the activation of estrogen receptors in diet-induced obese females, by reducing body weight and fat accumulation and improving leptin resistance at central level 53,54

Although it is well supported that ketogenesis from MCFA in the liver supplies the brain with alternative fuel with certain procognitive benefits, at this point, it is still an open question to what extent and which beneficial effects of MCFAs are mediated through KB and which through MCFA

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Also, one study 12 reported only mild AEs with ALC (dry mouth, n=1