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"It's not any different than hypertension or diabetes or the many other chronic illnesses that we deal with, where you have to use chronic medication." For over the past three years, the arrival of a new class of drugs known as GLP-1 agonists, so-called for their ability to mimic the action of the natural GLP-1 gut hormone that promotes satiety, has transformed the weight-loss field

Being a slow responder to GLP-1 medications (like semaglutide or tirzepatide) does not mean the medication has failed and it does not mean your body is broken

Journal of Advanced Nursing, 75 (1), 3042

Both medications require a gradual increase in dosage to minimize side effects and help the body adjust, but Wegovys titration schedule is longer (16-20 weeks versus 4 weeks for Contrave)