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Trials that have examined efficacy of GLP-1RA therapies include Evaluation of Lixisenatide in Acute Coronary Syndrome [ELIXA] trial, 47 Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results [LEADER] trial, 6 Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes [SUSTAIN-6], 49 oral administration of semaglutide in the Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 Diabetes [PIONEER-6], 50 once-weekly exenatide in the Exenatide Study of Cardiovascular Event Lowering [EXSCEL] trial, 51 albiglutide in the Harmony Outcomes trial, 52 and dulaglutide in the Researching Cardiovascular Events With a Weekly Incretin in Diabetes [REWIND] trial, 53 among others

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While the efficacy of herbal GLP-1 patches is doubtful and GLP-1 drug patches are still under trial, this delivery system through skin is said to have some potential benefits like 6 : Note: The benefits mentioned above are only theoretical as there are no GLP-1 patches which are FDA approved