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Some of these effects are in fact analogous to those previously observed by reducing beta cell/islet cholesterol with simvastatin: for example, both manipulations led to a reduction in GLP-1R plasma membrane lateral diffusion under vehicle conditions, as well as acute increases in GLP-1R-induced cAMP and islet insulin secretion responses
For many patients, injectable medications have offered effective results but have also presented practical or psychological barriers related to needles, dosing comfort, or self-administration
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doi:10.1016/j.disamonth.2021.101287
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