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NICE Technology Appraisal guidance (TA875 for semaglutide/Wegovy and TA664 for liraglutide/Saxenda) recommends these medications for weight management in adults with: A body mass index (BMI) of at least 35 kg/m and At least one weight-related comorbidity (such as type 2 diabetes, hypertension, dyslipidaemia, obstructive sleep apnoea, or non-alcoholic fatty liver disease) For liraglutide (Saxenda), NICE TA664 specifies additional criteria including prediabetes (HbA1c 42-47 mmol/mol or fasting plasma glucose 5.5-6.9 mmol/L) or high risk of cardiovascular disease
Despite the critical role of pericyte-mediated capillary constriction not yet being broadly known in the cardiac community 11 , this finding has been independently reproduced for the heart 12
Oral administration is ineffective due to peptide degradation in the digestive system
Theyre often tied to slowed digestion and tend to subside over time
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