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Previously, we have already developed and validated a similar PET marker for the GLP1R receptor, [ 68 Ga]Ga-DO3A-Exendin-4, in non-human primates 9,10
Even though the pathophysiology of these conditions is well understood, it has not been adequately translated into effective treatments to stop or reverse the course of the disease ( One of the key challenges in developing effective therapies against NDs is the blood-brain barrier (BBB) which is very selective hence, hinders the delivery of therapeutic agents to the brain ( Recent breakthroughs in nanotechnology have provided novel approaches for overcoming the BBB
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