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Similar content being viewed by others Subjects Introduction The glucagon-like peptide-1 receptor (GLP-1R), is a prototypical class B GPCR involved in the regulation of glucose homeostasis, food intake, inflammation and hypertension [1, 2]
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Oxidative Stress Parameters in Brain Areas On PND 28, animals were euthanized, and the brain was removed and dissected into specific regions of interest: frontal cortex, hypothalamus, hippocampus, striatum, posterior cortex, and cerebellum
In vitro , Ras palmitoylation promotes stress kinase activation through the Tiam1-Rac1-Nox2 signaling module, leading to mitochondrial dysfunction and endothelial cell apoptosis that drive the progression of diabetic retinopathy, whereas 2-BP is able to inhibit high-glucose-induced p38 MAPK activation and mitochondrial DNA damage, and targeted intervention of these pathways may provide a new strategy for the early control and prevention of diabetic vision loss (235)
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