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Maintaining basal-bolus GLP-1 levels as a treatment approach These studies have clearly shown that MBS corrects post-prandial GLP-1 responses in people with obesity but does not improve fasting GLP-1 levels, which remain lower in some patients as compared to normal-weight individuals

The American Diabetes Association (ADA) Standards of Care emphasize individualized therapy selection, with GLP-1 receptor agonists considered preferred agents for many patients with type 2 diabetes who require additional glucose-lowering therapy beyond metformin, particularly those with established cardiovascular disease or chronic kidney disease

Metoclopramide: risk of neurological adverse effects restricted indications, new contraindications, and reduced dose and duration of use

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