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GST Expression and Purification Protocols Recombinant human GSTA1, M1, M2, and P1 proteins were expressed in E

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This is probably explained by the fact that S-adenosylmethionine (SAM), which is important for many epigenetic processes, is regenerated by methylcobalamin, whereas cyanocobalamin reduces it (as we explored above)

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Table: Five-year cost projection by patient type Projections assume 20% price reductions with early biosimilar entry (2029) and 40% reductions with mature competition (2032), consistent with historical biosimilar pricing patterns (Mulcahy et al., RAND 2024)

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