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Data availability The data sets during the current study are available upon reasonable request to the corresponding authors

Colestipol (decrease cobalamin and folate absorption) Methotrexate (inhibits DHFR) Nitrous Oxide (inactivates MS) High Dose Niacin (depletes SAMe and limits pyridoxal kinase = active B6) Theophylline (limits pyridoxal kinase = active B6) Cyclosporin A (decreases renal function and increases Hcy) Metformin (decreases cobalamin absorption) Phenytoin (folate antagonist) Carbamazepine (folate antagonist) Oral Contraceptives (deplete folate) Antimalarials JPC-2056, Pyrimethamine, Proguanil (inhibits DHFR) Antibiotic Trimethoprim (inhibits DHFR) Ethanol Bactrim (inhibits DHFR) Sulfasalazine (inhibits DHFR) Triamterene (inhibits DHFR) Involving yourself with providers who are educated on MTHFR Take supplements that are methylation supportive L-5-MTHF Riboflavin (B2) Methylcobalamin or Hydroxocobalamin Zinc DHA Choline TMG (must be avoided in pregnancy) Magnesium Methyl- B6 NAC Vitamin E (natural forms only) Selenium Glutathione Vitamin C Vitamin D Potassium Probiotics Molybdenum Milk Thistle *****Avoid gluten as 20% of patients with MTHFR have gluten sensitivity and gluten is inflammatory

10.9787/PBB.2016.4.1.61 4 AllocatiN.FedericiL.MasulliM.Di IlioC

What Are the Symptoms of Glutathione Deficiency