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It serves as a cofactor for the methionine synthase enzyme, which transfers methyl groups to enable the regeneration of methionine from homocysteine

Methods Animals Animal experiments were performed with adherence to all national and local guidelines and regulations, the Guide for the Care and Use of Laboratory Animals 25 , and the ARRIVE guidelines, and with the approval of the Institutional Animal Care and Use Committee at The University of Texas Medical Branch (UTMB)