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In in vitro cell experiments using 3T3L1 preadipocytes as a model, treatment with NNMTi significantly reduced preadipocyte differentiation efficiency and markedly downregulated the expression of adipocyte markers (such as PPAR and C/EBP) in a dosedependent manner
Secondary endpoints assessed the patients ability to maintain a forced vital capacity over 60%, ambulate, and breathe independently without the need for noninvasive or invasive ventilatory support
Known deficiency, prior low B12, fatigue follow-up, diet-related risk, and histories that can affect absorption are the most common reasons patients ask for B12 injections
Higher energy demand on smaller intake
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