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These findings suggest that the effectiveness of oral semaglutide in reducing HbA1c levels was preserved in individuals who took the drug at times other than the morning fast, provided that a pre- and post-dose fasting was respected

Semaglutide tends to be the better fit when: the goal is a 10 to 15 percent weight reduction, the patient has documented cardiovascular disease or is at high cardiovascular risk and wants the medication with the most outcomes data, cost or access constraints favor it, or the patient has tolerated single-pathway GLP-1s well in the past

Weight regain after discontinuation is a major concern with all GLP-1 medications

Patients with diabetic retinopathy, renal impairment, or acute gallbladder disease require dose adjustments or alternative therapies