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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation
ClinicalTrials.gov (2026) Related Dosing Protocols Educational use only This guide is an educational research reference, not medical advice or a treatment plan
J., & Ng, F
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