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Cerebral microvascular endothelial glycocalyx damage, its implications on the bloodbrain barrier and a possible contributor to cognitive impairment

Pallidotomy studies (Leksell posteroventral pallidotomy procedures) 58 revealed that lesions in the internal segment of the globus pallidus (GPi) could help control symptoms of bradykinesia, rigidity, tremor, and dyskinesias 53,54 , while lesions in the subthalamic nucleus (STN) of the nonhuman primate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD also markedly improved Parkinsonian symptoms 59

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This process is detected through the fluorescence emitted by DCF in response to the oxidation of DCFH by ROS (Kim and Xue 2020)