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Klicznik MM, Morawski PA, Hllbacher B, et al
Braaks staging theory, backed by postmortem and animal model evidence, suggests that misfolded -synuclein aggregates initially arise in the enteric nervous system (ENS) and olfactory bulb, then spread to the midbrain following trans-synaptic transmissions through the vagus nerve [15]
Since these early observations about homocysteine, most but not all studies have linked high levels of homocysteine with a modest increase in risk of heart disease and stroke
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