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Heart Rate Effects Change in Pulse at Week 48 (LS Mean, 95% CI) (Data from Supplementary Appendix, Table S12) Placebo: +0.4 bpm (1.5 to +2.3) Retatrutide 1 mg: +1.7 bpm (0.7 to +4.0) 4 mg (ID 2 mg): +3.0 bpm (+1.1 to +4.9) 4 mg (ID 4 mg): +3.2 bpm (+0.8 to +5.6) 8 mg (ID 2 mg): +4.3 bpm (+1.5 to +7.1) 8 mg (ID 4 mg): +5.2 bpm (+2.2 to +8.1) 12 mg (ID 2 mg): +6.0 bpm (+3.7 to +8.3) Interpretation Retatrutide induces a clear, dose-dependent increase in heart rate
In Study 1, we found that participants evaluated an individual who lost weight with a GLP-1 more harshly than an individual who lost weight via diet and exercise (i.e., higher in negative traits, lower in positive traits, more unhealthy, less willing to affiliate)
DPP-4 enzyme rapidly degrades active GLP-1, reducing its circulating half-life to just 2-3 minutes
10.1016/s0149-2918(03)80336-3 Clin
