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Here, stimuli in the surrounding micro-environment induce macrophages to adopt pro-inflammatory or anti-inflammatory phenotypes and functions, thereby mediating inflammatory/autoimmune or homeostatic/reparative responses, respectively (22, 54)

Any system, tissue and organ in the body can be affected, and there are over 118 medical conditions/symptoms that are either caused and/or provoked by this type of allergic response to foods including, but not limited to, arthritis, weight gain, fatigue, high blood pressure, arthritis, Celiac Disease, sinus conditions, asthma and various digestive disorders

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showed that p53 could indirectly trigger arachidonate 12-lipoxygenase (ALOX12) function through transcriptional inhibition of SLC7A11, thus leading to ALOX12-dependent ferroptosis resulting from ROS stress (Chu et al., 2019)