21-23 Phase 2/3 trials are currently evaluating whether GLP-1 RAs reduce illness progression in persons with mild cognitive impairment or amyloid-positive mild dementia due to Alzheimer disease (ie, semaglutide)
26 One case report described a 50-year-old female with T2DM who presented to the ED with constipation, fatigue, and reduced oral intake for 3 days prior to admission
Proteomic analyses revealed that NNMT inhibition uniquely upregulated proteins involved in translation initiation, ribosomal biogenesis, and inflammatory regulation during muscle regeneration, suggesting multiple complementary mechanisms supporting muscle function
Symptoms include shakiness, sweating, hunger, anxiety, confusion, dizziness, blurred vision, and at the severe end, seizure or loss of consciousness