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He M et al

In second protocol, feeding experiments were started at 19:30 in male mice which had been deprived of food for 3 h (16:3019:30) with free access to water

For example, if your genetic profile shows reduced GLP1R sensitivity, your dose strategy may differ compared to someone with optimal receptor expression

In terms of the primary outcome of reduction in A1C from baseline, although the 3-mg oral semaglutide group did not demonstrate superiority to sitagliptin 100 mg at 26 weeks, the 7-mg and 14-mg dosage groups did demonstrate statistically significant reductions in A1C from baseline when compared with sitagliptin