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The authors concluded that such a programmable and stimuli-responsive nanohydrogel can be explored further as a cancer therapeutic (Li et al., 2019), however, this study was confined to the in vitro level and its execution to an in vivo level necessitates additional studies, such as the suitable route of administration, immunogenicity, general toxicity, metabolic stability, and suitable pharmacokinetic profile

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The study also identified hypoxia inducible factor-1 (HIF-1) as a potential regulator of synaptosome phagocytosis (Sharoar et al., 2021)

They provide potential benefits beyond skin whitening, including detoxification and enhanced immune function