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But the story does not end with dual agonism
Additional studies note its role in influencing pigmentation recovery in experimental scar tissue and in mitigating UV-induced skin damage models
These pathways are mediated by factors like PPAR coactivator 1 (PGC-1) and fibroblast growth factor 21 (FGF21) (75)
Newer methods, such as Fluorescence-Activated Cell Sorting-based nuclear isolation and single-cell or single-nucleus epigenomic profiling, are only now allowing researchers to look past these averaged signals and observe epigenetic changes at true cellular resolution
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