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Selective small molecule agonists have been developed to activate many of these receptors, notably G protein-coupled receptor 40 (GPR40 [free fatty acid receptor (FFAR) 1]), GPR119 and GPR120 (FFAR4), and several have shown efficacy in animal models
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Hepatic Lipid Metabolism Researchers studying NAFLD and MASH models have examined retatrutide's effect on hepatic triglyceride content, where glucagon-receptor agonism is hypothesized to drive intrahepatic lipid mobilization beyond what GLP-1 alone produces
This constant elevation can cause significant side effects including insulin resistance, carpal tunnel syndrome, fluid retention, and potential concerns about stimulating abnormal tissue growth
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