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Toh EYJ, Ng JSP, McIntyre RS, et al
Accordingly, in vitro and ex vivo studies have shown that exposure to saxagliptin (135, 136) but not sitagliptin (136), results in altered cardiac electrophysiology and is associated with impaired cardiomyocyte contractility
Procedures such as gastric bypass or sleeve gastrectomy have demonstrated significant long-term weight loss and improvement in obesity-related comorbidities, though patients require lifelong monitoring including thyroid function assessment, as malabsorption may affect levothyroxine requirements
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