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The critical distinction from PDE5 inhibitors lies in the direction of causation

doi: 10.1212/CPJ.0000000000001007 22

Glucagon remains below 0.3% even at 15 mg, ruling out the glucagon-driven liver and heart effects seen with retatrutide. GIPR: the identity receptor At the 2.5 mg starter dose, GIP receptor occupancy is already about 13%

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