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Elimination Metabolism Acetaminophen is primarily metabolized in the liver by first-order kinetics and involves three principal separate pathways: Conjugation with glucuronide, conjugation with sulfate, and oxidation via the cytochrome P450 enzyme pathway, primarily CYP2E1, to form a reactive intermediate metabolite (N-acetyl-p-benzoquinone imine or NAPQI)
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Start with 0.5-1mg daily if injecting, or a 1-2% topical product applied once daily
Phase I consist primarily of microsomal enzymes, which are found abundantly in the liver, gastrointestinal tract, lung and kidney, consisting of families and subfamilies of enzymes that are classified based on their amino acid sequence identities or similarities
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