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In mice model single dosage of 150 mg per kg of cyclophosphamide was administered intraperitoneally then different icariin doses were administered intraperitoneally such as 5 mg, 25 mg, and 50 mg per kg were shown to reduce visceral reflexes and nociception

Additionally, surgery often involves anesthesia drugs that can directly or indirectly affect mitochondria e.g

Although pre-clinical and clinical confirmation is required, these studies suggest that PTC may in part be driven by UCA1 acting as a ceRNA to suppress miR-204-5p and stimulate oncogenic IGFBP-5 [70]

Gut Repair Post-Surgery Research also looks at BPC-157 for its potential in promoting the healing of the intestines after surgeries like intestinal resections or bariatric surgery