The effect of DMF (dimethyl fumarate) on gene expression of proapoptotic (caspase 3), antiapoptotic B-cell lymphoma 2 (Bcl-2), nuclear factor erythroid 2-related factor 2 (Nrf2), and heme oxygenase 1 (HO-l) in the liver of MTX (methotrexate)-injured mice
FIGURE 3 To verify that these phenomena were indeed caused by GPX4 activation, we tested the effects of compound 102 on other seven enzymes in the AA network, including COX-1, COX-2, mPGES-1, 5-LOX, LTA 4 H, 12-LOX, and 15-LOX
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