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Figure 2 2.3 Clinical implications The triple-hit paradigm shifts the understanding of PDM from an autoimmune and insulin resistant process to one that is fibro-inflammatory, malabsorptive, and bihormonal deficient ( 2.4 Pathophysiologic endotypes of PDM The relationships between Chronic Pancreatitis, Pancreatic Ductal Adenocarcinoma, Cystic Fibrosis, and pancreatectomy are centered on pancreatogenic diabetes, yet these conditions have different driving mechanisms behind dysglycaemia

This positions the drug as a potential preemptive treatment

Patients experiencing severe abdominal pain, persistent vomiting, signs of infection, or allergic reactions should seek urgent medical attention