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Moreover, Tet3-KD neurons or Tetrodotoxin-induced decreases in Tet3 expression exhibited increased CpG methylation at the BDNF promoter IV region, whereas bicuculline-induced increases in Tet3 expression were shown to be associated with decreased methylation at the same region, supporting a pivotal role of Tet3 in regulating gene expression in response to global synaptic activity changes [54]

But it has one well-known vulnerability: stability, particularly in solution and in varying pH environments