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One possibility is that GLP-1R endocytosis is required for agonist uptake by the brain via hypothalamic tanycytes, as described for leptin 65

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A properly dosed GLP-1 might bring these down to 115 mg/dL (6.4 mmol/L) pre-meal and 160 mg/dL (8.9 mmol/L) after meals within 8-12 weeks

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