slc25a39 is necessary for mitochondrial glutathione import in mammalian cells concentration mitochondria Cellular Compartmentalization, Transport and Its Relevance Some Pathologies – SLC25A39 identified as a key

For example, in studies where skin fibroblasts were treated with GHK-Cu, there was increased expression of extracellular matrix genes and antioxidant enzymes

Increased levels of free fatty acids and liquid droplets were detected in iPSC-derived motor neurons from C9orf72 ALS/FTD patients, suggesting the presence of dysregulated lipid metabolism by free fatty acid synthesis (Liu Y

This can leave mitochondrial membranes, enzymes and DNA more vulnerable to oxidative injury

Wongchitrat P, Shukla M, Sharma R et al (2021) Role of melatonin on virus-induced neuropathogenesisa concomitant therapeutic strategy to understand SARS-CoV-2 infection