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But the additive benefit of combining them remains theoretical

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Upon treating mucinous lung adenocarcinoma with the EGFR inhibitor gefitinib, the EGFR ligand amphiregulin promotes the binding of IGF-IR to importin-1 and triggers nuclear localization of IGF-IR, which in turn prevents the induction of apoptosis by gefitinib [117]

Oxidative stress occurs when there is an imbalance between free radicals and antioxidants