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doi: 10.1099/mic.0.26012-0 56 WangGMaierRJ

For payloads requiring high stability, such as those that degrade or deactivate easily in the bloodstream, non-cleavable linkers can better ensure drug integrity and safety during delivery

This attention to quality control ensures researchers can maintain consistent experimental conditions and get reproducible results across multiple studies

It is proposed to work by binding GHRH receptors on pituitary somatotroph cells, prompting the pituitary to synthesize and release its own growth hormone in a pulsatile pattern, with the body's somatostatin feedback loop still intact so the effect is self-limiting rather than a constant hormone flood