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Weis et al

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Although endothelial activation and redox signaling compose a normal host defense, when this activation is sustained, chronic production of ROS may exceed the capacity of cellular enzymatic and nonenzymatic antioxidant defenses [49], contributing to triggering vascular diseases such as atherosclerosis or peripheral artery disease [102, 103]

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This is why it's important to review your supplement stack with a healthcare professional, like a Midi clinician

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